The SPINAQUA team performed a series of controlled, large-scale laboratory experiments at the Aqualabs facilities of IMBBC-HCMR (Crete), in order to assess the cleanup capacity of four sponge species against microalgae. Specific microalgae were selected as a model for the biological pollution typically encountered in fish aquaculture settings. Sponge fragments were placed in flasks containing natural seawater and microalgae were added. The clearance/removal rates of microalgae were determined by fluorescence microplate reader analysis.